Piperidine alkaloids: Human and food animal teratogens
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چکیده
منابع مشابه
Piperidine alkaloids: human and food animal teratogens.
Piperidine alkaloids are acutely toxic to adult livestock species and produce musculoskeletal deformities in neonatal animals. These teratogenic effects include multiple congenital contracture (MCC) deformities and cleft palate in cattle, pigs, sheep, and goats. Poisonous plants containing teratogenic piperidine alkaloids include poison hemlock (Conium maculatum), lupine (Lupinus spp.), and tob...
متن کاملSynthetic Studies of Alkaloids Containing Pyrrolidine and Piperidine Structural Motifs
Our molecules of interest were mainly 2-substituted pyrrolidine and piperidine alkaloids containing 1, 3-aminoketone and 1, 3-aminoalcohol units which are of special synthetic interest (Figure 1). Hygrine and norhygrine belong to the class of tropane alkaloids. The rest of the alkaloids are isolated from 60 species of the genus Sedum and are usually referred as Sedum alkaloids which are of imme...
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Andrachne aspera, a small perennial undershrub, is commonly found in the arid, stony and sandy regions of Pakistan. Medicinally, this plant is used to improve eyesight and to treat eye sores2−3. A crude alkaloidal mixture has been reported to show various biological activities. The biological significance of A. aspera motivated us to reinvestigate for further alkaloidal constituents fourteen ye...
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Drugs administered to the mother can affect the fetus by preventing implantation or by causing resorption of the embryo, abortion or intrauterine death. It is a sobering thought that the first of these mechanisms is dignified by the name 'contraception' and that the remainder have far less medicolegal and economic significance than the survival of a defective fetus after a less drastic chemical...
متن کاملTeratogens and Their Effects
A congenital malformation is an anatomical or structural abnormality present at birth. Congenital malformations may be caused by genetic factors or environmental insults or a combination of the two that occur during prenatal development. Most common congenital malformations demonstrate multifactorial inheritance with a threshold effect and are determined by a combination of genetic and environm...
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ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2012
ISSN: 0278-6915
DOI: 10.1016/j.fct.2012.03.049